翻訳と辞書 Words near each other ・ Automated firearms identification ・ Automated Flight Following ・ Automated fueling ・ Automated guided vehicle ・ Automated guideway transit ・ Automated Housing Referral Network ・ Automated Imaging Association ・ Autoimmune enteropathy ・ Autoimmune estrogen dermatitis ・ Autoimmune gastrointestinal dysmotility ・ Autoimmune heart disease ・ Autoimmune hemolytic anemia ・ Autoimmune hepatitis ・ Autoimmune hypophysitis ・ Autoimmune inner ear disease ・ Autoimmune lymphoproliferative syndrome ・ Autoimmune neutropenia ・ Autoimmune Oophoritis ・ Autoimmune optic neuropathy ・ Autoimmune pancreatitis ・ Autoimmune polyendocrine syndrome ・ Autoimmune polyendocrine syndrome type 1 ・ Autoimmune polyendocrine syndrome type 2 ・ Autoimmune polyendocrine syndrome type 3 ・ Autoimmune progesterone dermatitis ・ Autoimmune regulator ・ Autoimmune retinopathy ・ Autoimmune thyroiditis ・ Autoimmune/inflammatory syndrome induced by adjuvants ・ Autoimmunity Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Autoimmune lymphoproliferative syndrome ： ウィキペディア英語版 Autoimmune lymphoproliferative syndrome Autoimmune lymphoproliferative syndrome (ALPS), also known as Canale-Smith syndrome,〔Straus SE, Jaffe ES, Puck JM et al. The development of lymphomas in families with autoimmune lymphoproliferative syndrome with germline Fas mutations and defective lymphocyte apoptosis. Blood. 2001 Jul 1;98(1):194-200. PMID 11418480〕 is a form of lymphoproliferative disorder (LPDs). It affects lymphocyte apoptosis.〔 It is a RASopathy. It is a rare genetic disorder of abnormal lymphocyte survival caused by defective Fas mediated apoptosis.〔 Normally, after infectious insult, the immune system down-regulates by increasing Fas expression on activated B and T lymphocytes and Fas-ligand on activated T lymphocytes. Fas and Fas-ligand interact to trigger the caspase cascade, leading to cell apoptosis. Patients with ALPS have a defect in this apoptotic pathway, leading to chronic non-malignant lymphoproliferation, autoimmune disease, and secondary cancers.〔 ==Genetics== This condition is usually caused by mutations in the FAS gene. Rarely cases due to mutations in other genes including the FAS ligand gene have been reported.〔Magerus-Chatinet A, Stolzenberg MC, Lanzarotti N, Neven B, Daussy C, Picard C, Neveux N, Desai M, Rao M, Ghosh K, Madkaikar M, Fischer A, Rieux-Laucat F (2012) Autoimmune lymphoproliferative syndrome caused by a homozygous null FAS ligand (FASLG) mutation. J Allergy Clin Immunol〕 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Autoimmune lymphoproliferative syndrome」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.